There are a few instances when it would not be appropriate to take a photograph. If someone is in the middle of a private moment, or if they are in a place where they are not expecting to be photographed, it is best to err on the side of caution and not take a picture. If someone looks like they are in distress, or if they are in a dangerous situation, it is also best to refrain from taking a photograph. In general, if you are unsure whether or not it is ok to take a photograph, it is best to ask for permission first.